Fragment-oriented synthesis: β-elaboration of cyclic amine fragments using enecarbamates as platform intermediates. Issue 62 (6th July 2020)

• Record Type: Journal Article
• Authors: Trindade, Alexandre F.; Faulkner, Emily L.; Leach, Andrew G.; Nelson, Adam; Marsden, Stephen P.
• Is Part Of: Chemical communications. Volume 56:Issue 62(2020)
• Page Start: 8802
• Page End: 8805
• Publication Date: 2020-07-06
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc03934a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Selective β-sp 3 functionalisation of cyclic amines is achieved through enecarbamate formation and photoredox-catalysed derivatisation with functionalised alkyl halides. Abstract : A strategy for the β-sp 3 functionalisation of cyclic amines is described. Regioselective conversion of protected amines to enecarbamates is achieved through electrochemical oxidation; these intermediates can be derivatised by functionalised alkyl halides under photoredox catalysis. The potential of the methods is highlighted by direct growth of a DCP2B-binding fragment.