Nanogel receptors for high isoelectric point protein detection: influence of electrostatic and covalent polymer–protein interactions. Issue 45 (4th May 2020)

• Record Type: Journal Article
• Authors: Wechsler, Marissa E.; Dang, H. K. H. Jocelyn; Dahlhauser, Samuel D.; Simmonds, Susana P.; Reuther, James F.; Wyse, Jordyn M.; VandeWalle, Abigail N.; Anslyn, Eric V.; Peppas, Nicholas A.
• Is Part Of: Chemical communications. Volume 56:Issue 45(2020)
• Page Start: 6141
• Page End: 6144
• Publication Date: 2020-05-04
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc02200d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Synthesis of an aldehyde acrylate-based functional monomer and incorporation into poly( N -isopropylacrylamide- co -methacrylic acid) nanogels for use as high pI protein receptors. Abstract : An aldehyde acrylate-based functional monomer was incorporated into poly( N -isopropylacrylamide- co -methacrylic acid) nanogels for use as protein receptors. The aldehyde component forms dynamic imines with surface exposed lysine residues, while carboxylic acid/carboxylate moieties form electrostatic interactions with high isoelectric point proteins. Together, these interactions effect protein adsorption and recognition.