A self-healable, moldable and bioactive biomaterial gum for personalised and wearable drug delivery. Issue 19 (4th May 2020)

• Record Type: Journal Article
• Authors: Shahbazi, Mohammad-Ali; Shrestha, Neha; Pierchala, Malgorzata Karolina; Kadumudi, Firoz Babu; Mehrali, Mehdi; Hasany, Masoud; Préat, Véronique; Leeuwenburgh, Sander; Dolatshahi-Pirouz, Alireza
• Is Part Of: Journal of materials chemistry. Volume 8:Issue 19(2020)
• Page Start: 4340
• Page End: 4356
• Publication Date: 2020-05-04
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c9tb02156f
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : A polymeric gum has been developed herein, which combines high stretchability and self-healing capacity with a bioactivity that can target and eliminate bacterial infections and inflammations. Abstract : One of the long-standing challenges in materials science involves synthesizing biomaterials that recapitulate important features of native biological tissues. Even though, the number of available biomaterials at the moment are virtually limitless, few of them has unlocked all the secrets of the human body by mimicking the combinatorial-like material properties of our tissues and organs. Inspired by the human body, we have developed a polymeric gum, which combines stretchability, toughness, strength, flexibility, and self-healing. It also exhibits a high bioactivity that can target and eliminate bacterial infections fast and reliably. Notably, this material is moldable into almost any complex shape, and therefore suitable as a building block for wearables designed to conform directly with the curved and personalized anatomy of patients. It also exhibits excellent drug retention and release capacity, which altogether makes it suitable for applications in personalized wearable drug-delivery devices.