A novel elastic and controlled-release poly(ether-ester-urethane)urea scaffold for cartilage regeneration. Issue 18 (7th April 2020)

• Record Type: Journal Article
• Authors: Chen, Chang'an; Huang, Kai; Zhu, Jingjing; Bi, Yikang; Wang, Liren; Jiang, Jia; Zhu, Tonghe; Yan, Xiaoyu; Zhao, Jinzhong
• Is Part Of: Journal of materials chemistry. Volume 8:Issue 18(2020)
• Page Start: 4106
• Page End: 4121
• Publication Date: 2020-04-07
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c9tb02754h
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Combination of a novel elastic poly(ether-ester-urethane)urea scaffold and kartogenin for cartilage regeneration. Abstract : In the tissue engineering of cartilage, scaffolds with appropriate elasticity and controlled-release properties are essential. Herein, we synthesized a poly(ether-ester-urethane)urea scaffold with a pendant amino group (PEEUUN) through a de-protection process from PEEUU-Boc polymers and grafted kartogenin (KGN) onto the PEEUUN scaffolds (PEEUUN-KGN). Characterization, performance tests, scaffold biocompatibility analysis, and chondrogenesis evaluation both in vitro and in vivo were conducted. The results revealed that the PEEUUN-KGN scaffolds were degradable and three-dimensional (3D) with interconnected pores, and possessed good elasticity, as well as excellent cytocompatibility. Meanwhile, KGN on the PEEUUN-KGN scaffolds underwent stable sustained release for a long time and promoted human umbilical cord mesenchymal stem cells (HUCMSCs) to differentiate into chondrocytes in vitro, thus enhancing cartilage regeneration in vivo . In conclusion, the present PEEUUN-KGN scaffolds would have application potential for cartilage tissue engineering.