I2-Catalyzed transformation of o-aminobenzamide to o-ureidobenzonitrile using isothiocyanates. Issue 14 (23rd March 2020)

• Record Type: Journal Article
• Authors: Shamanth, Sadashivamurthy; Chaithra, Nagaraju; Gurukiran, Mahesha; Mamatha, Mahesha; Lokanath, N. K.; Rangappa, Kanchugarakoppal S.; Mantelingu, Kempegowda
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 14(2020)
• Page Start: 2678
• Page End: 2684
• Publication Date: 2020-03-23
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob00118j
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : The present work describes an unexpected and unique protocol for the iodine catalysed synthesis of o -ureidobenzonitriles using o -aminobenzamides and isothiocyanates via intramolecular rearrangement. Abstract : The present work describes an unexpected and unique protocol for the iodine catalysed synthesis of o -ureidobenzonitriles using o -aminobenzamides and isothiocyanates via intramolecular rearrangement. The metal-free route achieved here is insensitive to moisture and applicable to the synthesis of a wide variety of o -ureidobenzonitriles with excellent yields even in a scalable fashion.