Ethyl acetate as solvent for the synthesis of poly(2-ethyl-2-oxazoline). Issue 5 (19th February 2020)

• Record Type: Journal Article
• Authors: Vergaelen, Maarten; Verbraeken, Bart; Van Guyse, Joachim F. R.; Podevyn, Annelore; Tigrine, Ali; de la Rosa, Victor R.; Monnery, Bryn D.; Hoogenboom, Richard
• Is Part Of: Green chemistry. Volume 22:Issue 5(2020)
• Page Start: 1747
• Page End: 1753
• Publication Date: 2020-02-19
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c9gc03872h
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : Addressing the polymerization of 2-ethyl-2-oxazoline (EtOx) in ethyl acetate to replace the current state-of-the-art solvents. The switch to ethyl acetate is important towards pharmaceutical compliance/compatibility of PEtOx, besides low environmental burden. Abstract : Poly(2-ethyl-2-oxazoline) (PEtOx) is the most common poly(2-oxazoline) for biomedical applications resulting from its high water-solubility, good commercial availability and well-controlled polymerization. In this article, we report the polymerization of 2-ethyl-2-oxazoline (EtOx) in ethyl acetate to replace the current state-of-the-art polymerization of EtOx in acetonitrile and chlorobenzene. This switch towards ethyl acetate as green solvent is an important improvement towards pharmaceutical compliance/compatibility, besides the lower burden for the environment.