Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography. Issue 21 (27th March 2020) - Mazzoccanti, Giulia
Abstract : A simple and effective chromatographic method has allowed unprecedented resolution of basic peptide and their related impurities, including the very challenging epimeric isobaric ones. Abstract : The application of a novel chromatographic approach to therapeutic peptides bearing basic amino acids in their structure allowed unprecedented resolution of their related impurities (including epimeric isobaric ones), resulting in a superior analytical tool for the evaluation of the quality of these drugs in the market.