Large population-based study using the SEER database: is endoscopic resection appropriate for early gastric cancer patients in the United States?. (2nd July 2020)

• Record Type: Journal Article
• Authors: Yang, Bo; Sun, Kaidi; Hui, Yangyang; Zhu, Lanping; Wang, Saiyu; Ma, Shuang; Yu, Zihan; Zhao, Jing; Liu, Qinlingfei; Zhao, Jingwen; Chen, Xin
• Is Part Of: Scandinavian journal of gastroenterology. Volume 55:Number 7(2020)
• Page Start: 834
• Page End: 842
• Publication Date: 2020-07-02
• Subjects: Early gastric cancer -- cancer-specific survival -- overall survival -- lymph node metastasis -- surveillance -- epidemiology -- and End Result database; Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; 616.33
• DOI: 10.1080/00365521.2020.1786158
• Languages: English
• ISSNs: 0036-5521

Abstract

Abstract: Aim: To investigate whether endoscopic treatment is applicable to American patients and explores the predictors of lymph node metastasis (LNM) in early gastric cancer (EGC). Methods: Patients with EGC confined to either mucosa (T1a, n = 1799) and submucosa (T1b, n = 1689) were identified from the Surveillance, Epidemiology, and End Result database. Multivariate logistic regression, Kaplan–Meier method, and univariate/multivariate Cox regression were used to assess the correlation between invasion depth and LNM or prognosis. A nomogram for predicting LNM was constructed and internally validated. Results: EGC limited to T1a exhibited a 2.4% incidence of LNM, which increased to 11.1% when the depth invaded T1b.LNM was present at 1.4%, 5.2%, and 5.0% for sizes ≤2, 2–5, and >5cm of low-grade T1a EGC, respectively, ( p = .019) and at 4.8%, 12.4%, and 28.6% of T1b EGC, respectively ( p < .001).The multivariate logistic model revealed that older age, T1b invasion, larger tumor size, and high-grade lesions were associated with a higher risk of LNM. Moreover, the T1a EGC patients had better cancer-specific survival (OS) and overall survival(CSS) compared with the T1b EGC patients (5-year OS: 77.2% versus 67.4%, p < .001; 5-year CSS: 90.6% versus 81.4%, p < .001). The discrimination of the prediction model was 0.745. Conclusions: Endoscopic treatment may only be suitable for patients in the US population who have low-grade T1a lesions of less than 2 cm in size. Patients with T1a lesions of greater than 2 cm in size, lesions with high-grade, and all T1b lesions may benefit from radical surgical resection with lymphadenectomy.