Functional terpyridyl iron complexes for in vivo photoacoustic imaging. Issue 15 (22nd June 2020)

• Record Type: Journal Article
• Authors: Xiang, Pan; Shen, Yu; Shen, Jie; Feng, Zhihui; Sun, Min; Zhang, Qiong; Li, Shengli; Li, Dandan; Zhang, Guilong; Wu, Zhengyan; Tian, Yupeng; Zhang, Zhongping; Tian, Xiaohe
• Is Part Of: Inorganic chemistry frontiers. Volume 7:Issue 15(2020)
• Page Start: 2753
• Page End: 2758
• Publication Date: 2020-06-22
• Subjects: Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/d0qi00058b
• Languages: English
• ISSNs: 2052-1553

Abstract

Abstract : Photoacoustic (PA) imaging has received extensive attention in the recent decade due to its ultra-high resolution in deep tissue penetration. Abstract : Photoacoustic (PA) imaging has received extensive attention in the recent decade due to its ultra-high resolution in deep tissue penetration, whereas functional PA probes with tunable molecular structure at a low cost level remain a significant challenge. Herein, we have rationally designed three triple-pyridyl iron complexes with different water solubilities. These complexes show a higher photothermal conversion efficiency due to their rapid excited-state deactivation, making them suitable as PA probes. Notably, the photothermal conversion efficiency of one complex named S-Fe could reach as high as 29.6%. In addition, S-Fe has excellent solubility and biocompatibility, which enable PA imaging in vivo . Significantly, further pharmacokinetics evaluation demonstrated that this complex showed minimal invasiveness for live animals and displayed a relatively fast metabolism rate. This study using inexpensive iron complexes as PA agents upgraded the toolbox for PA imaging and correlated multi-modal imaging applications.