Polytopic carriers for platinum ions: from digalloyl depside to tannic acid. (8th July 2020)

• Record Type: Journal Article
• Authors: Fogagnolo, Marco; Bergamini, Paola; Marchesi, Elena; Marvelli, Lorenza; Gambari, Roberto; Lampronti, Ilaria
• Is Part Of: New journal of chemistry. Volume 44:Number 28(2020)
• Page Start: 12227
• Page End: 12235
• Publication Date: 2020-07-08
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d0nj01352h
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : Multinuclear platinum complexes of the natural antioxidant tannic acid and its aglycone part methyl digallate can be prepared via an environmentally friendly, solvent-free process exploiting the convenient precursor [PtCO3 (Me2 SO- S )2 ]. Abstract : A novel dinuclear platinum(ii ) complex, namely [Pt2 m -GG(Me2 SO- S )4 ] (8, GG = deprotonated methyl digallate), was easily synthesized under solvent-free conditions by grinding a solid m / p digalloyl depside with the Pt precursor [PtCO3 (Me2 SO- S )2 ]. Similarly, platinum nuclei were introduced into the galloyl chains of tannic acid (TA ). In particular, three complexes A, B and C were prepared by reacting TA as a polytopic ligand with an increasing amount of [PtCO3 (Me2 SO- S )2 ]. The antiproliferative activity of complexes 8, A, B and C together with the corresponding ligands GG and TA was tested in vitro and compared with that of cisplatin on two human tumor cell lines, A2780 (ovarian cisplatin-sensitive) and A2780 cis (ovarian cisplatin-resistant), and one non-tumoral cell line, HaCat. The experiments focusing on their pro-apoptotic activity indicated that the antiproliferative activity of the most active Pt(II) complexes is associated with the induction of apoptosis.