Ruthenocycles of benzothiazolyl and pyridyl hydrazones with ancillary PAHs: synthesis, structure, electrochemistry and antimicrobial activity. (19th June 2020)

• Record Type: Journal Article
• Authors: Dinda, Soumitra; Sultana, Tamanna; Sultana, Suhana; Patra, Sarat Chandra; Mitra, Arup Kumar; Roy, Subhadip; Pramanik, Kausikisankar; Ganguly, Sanjib
• Is Part Of: New journal of chemistry. Volume 44:Number 26(2020)
• Page Start: 11022
• Page End: 11034
• Publication Date: 2020-06-19
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d0nj01447h
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : The antimicrobial activity of ruthenocycles of pyridyl and benzothiazolyl hydrazones has been investigated. The study established that such activity is comparatively higher for the complex containing benzothiazolyl hydrazone. Abstract : Two types of bivalent ruthenium complexes [RuL Py (CO)Cl(PPh3 )3 ] 3 and [RuL Benz (CO)Cl(PPh3 )3 ] 4 were synthesized starting from [RuH(CO)Cl(PPh3 )3 ] and heterocyclic hydrazone ligands 1 and 2 respectively. X-ray diffraction studies reveal that in both types of complexes, the ligands behave as monoanionic bidentate Nhydrazonyl and Npyridyl /Nbenzothiazolyl donors towards ruthenium(ii ), thereby furnishing four-membered metallacycles. The multiple transitions in the electronic spectra have been elucidated by time dependent density functional theory (TDDFT). The redox active nature of both 3 and 4 has been substantiated from the well-defined oxidative responses and theoretical scrutiny corroborates that one of them is exclusively ligand centred while the other one is chiefly due to the Ru II /Ru III oxidation. Both the types of complexes exhibit a significant antimicrobial activity, although the activity of 4 is more prominent, particularly over Pseudomonas . These are analyzed by measuring ZOI, MIC as well as the extent of membrane damage and protein leakage studies. The complexes probably cause free-radical facilitated oxidative damage to the bacterial cells during the course of their activity.