Visible light-promoted ring-opening functionalization of three-membered carbo- and heterocycles. (20th March 2020)

• Record Type: Journal Article
• Authors: Xuan, Jun; He, Xiang-Kui; Xiao, Wen-Jing
• Is Part Of: Chemical Society reviews. Volume 49:Number 9(2020)
• Page Start: 2546
• Page End: 2556
• Publication Date: 2020-03-20
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cs00523d
• Languages: English
• ISSNs: 0306-0012

Abstract

Abstract : In this tutorial review, synthetic and mechanistic aspects of visible light-promoted ring-opening functionalization of three-membered carbo- and heterocycles are highlighted. Abstract : Due to their inherent ring strain, three-membered carbocyclic- and heterocyclic ring structures are versatile synthetic building blocks. Traditional ring-opening methods of these molecules require the use of thermolysis, acid catalysts or transition-metals via ionic reaction pathways. Recently, visible light-induced photoredox catalysis has emerged as a powerful platform for initiating new chemical transformations. In this tutorial review, the synthetic and mechanistic aspects of visible light-promoted ring-opening functionalization of three-membered carbo- and heterocycles are highlighted. By using these strategies, a variety of ring-opening functionalization products, including biologically important carbo- and heterocycles, can be efficiently accessed in a high chemo- and regioselective manner.