A nano-photosensitizer based on covalent organic framework nanosheets with high loading and therapeutic efficacy. Issue 13 (24th March 2020)

• Record Type: Journal Article
• Authors: Tong, Xiaoning; Gan, Shaoju; Wu, Jinhui; Hu, Yiqiao; Yuan, Ahu
• Is Part Of: Nanoscale. Volume 12:Issue 13(2020)
• Page Start: 7376
• Page End: 7382
• Publication Date: 2020-03-24
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c9nr10787h
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Covalent organic framework nanosheets were fabricated to disperse organic fluorescent phthalocyanines. The nano-photosensitizer exhibited high loading capacity of phthalocyanines, alleviated self-aggregation, and excellent photooxidation activity. Abstract : Photooxidation provides a promising strategy for photocatalysis, photodynamic therapy, and environmental protection. Unfortunately, most organic photosensitizers possess weak hydrophilicity and a π–π conjugated structure, leading to singlet oxygen self-quenching, poor loadability and therefore unsatisfactory photooxidation efficiency. Thus, dispersion of these photosensitizers within a two-dimensional porous covalent organic framework has become a feasible strategy to hinder their self-aggregation and augment their loading capacity. Here, we report a phthalocyanine-based photosensitizer loaded on covalent organic framework nanosheets. This nano-photosensitizer exhibits highly dispersed organic fluorescent phthalocyanines and a high loading capacity. The fabricated nanosheets restrict self-aggregation of photosensitizer molecules and enhance the photooxidation activity, which may offer a new paradigm for photooxidation and its multiple applications.