Benzimidazolium salts prevent and disrupt methicillin-resistant Staphylococcus aureus biofilms. Issue 16 (4th March 2020)

• Record Type: Journal Article
• Authors: Tessier, Jérémie; Schmitzer, Andreea R.
• Is Part Of: RSC advances. Volume 10:Issue 16(2020)
• Page Start: 9420
• Page End: 9430
• Publication Date: 2020-03-04
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d0ra00738b
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Benzimidazolium salts impair biofilm and bacterial membrane structural integrity. Abstract : Emergence of resistant bacteria encourages us to develop new antibiotics and strategies to compensate for the different mechanisms of resistance they acquire. One of the defense mechanisms of resistant bacteria is the formation of biofilms. Herein we show that benzimidazolium salts with various flexible or rigid side chains act as strong antibiotic and antibiofilm agents. We show that their antibiofilm activity is due to their capacity to destroy the biofilm matrix and the bacterial cellular membranes. These compounds are able to avoid the formation of biofilms and disperse mature biofilms showing a universal use in the treatment of biofilm-associated infections.