Transition-metal and oxidant-free approach for the synthesis of diverse N-heterocycles by TMSCl activation of isocyanides. Issue 49 (7th August 2020)

• Record Type: Journal Article
• Authors: Luo, Liangliang; Li, Hongyan; Liu, Jinxin; Zhou, Yuan; Dong, Lin; Xiao, You-Cai; Chen, Fen-Er
• Is Part Of: RSC advances. Volume 10:Issue 49(2020)
• Page Start: 29257
• Page End: 29262
• Publication Date: 2020-08-07
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d0ra04636a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A highly efficient TMSCl-mediated addition of N-nucleophiles to isocyanides has been achieved. Abstract : A highly efficient TMSCl-mediated addition of N-nucleophiles to isocyanides has been achieved. This transition-metal and oxidant-free strategy has been applied to the construction of various N-heterocyles such as quinazolinone, benzimidazole and benzothiazole derivatives by the use of distinct amino-based binucleophiles. The notable feature of this protocol includes its mild reaction condition, broad functional group tolerance and excellent yield.