Efficient iron catalyzed ligand-free access to acridines and acridinium ions. Issue 10 (8th April 2020)

• Record Type: Journal Article
• Authors: Mandal, Susanta; Chhetri, Karan; Bhuyan, Samuzal; Roy, Biswajit G.
• Is Part Of: Green chemistry. Volume 22:Issue 10(2020)
• Page Start: 3178
• Page End: 3185
• Publication Date: 2020-04-08
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/d0gc00617c
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : A general synthesis of both acridines and acridinium ions is descried from inexpensive and commercially available aliphatic starting materials using iron as catalyst and aerobic oxygen as oxidant in alcoholic solvent to produce water as only by product. Abstract : Acridines and acridinium ions are one of the important classes of compounds in terms of their usefulness in pharmaceuticals, materials, dyes and photo-catalysis. Here we present an unconventional FeCl3 -alcohol catalysed one-pot method for their synthesis directly from aldehydes, 1, 3-cyclohexanedione and amines. This method efficiently merged high atom-economy and diversity of multicomponent reaction with novel iron catalyzed dehydrogenation, using aerobic oxygen as the terminal oxidant, in alcoholic solvent to produce water as the only by-product. Easy scaling up of the method has been successfully demonstrated.