1, 3-Dipolar cycloaddition of isatin N, N′-cyclic azomethine imines with α, β-unsaturated aldehydes catalyzed by DBU in water. Issue 41 (25th June 2020)

• Record Type: Journal Article
• Authors: Wang, Zhan-Yong; Yang, Ting; Chen, Rongxiang; Ma, Xueji; Liu, Huan; Wang, Kai-Kai
• Is Part Of: RSC advances. Volume 10:Issue 41(2020)
• Page Start: 24288
• Page End: 24292
• Publication Date: 2020-06-25
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d0ra03806g
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A simple and green procedure was established by [3 + 3] cycloaddition reaction of isatin derived cyclic imine 1, 3-dipoles with α, β-unsaturated aldehydes, giving spirooxindoles with aza-quaternary center in good yields and diastereoselectivities. Abstract : A simple and green procedure was established by [3 + 3] cycloaddition reaction of isatin derived cyclic imine 1, 3-dipoles with α, β-unsaturated aldehydes, giving the desired spiro heterocyclic oxindoles with aza-quaternary centers in good yields and diastereoselectivities. It should be noted that water can be employed as a suitable solvent for the improvement of diastereoselectivity.