Copper-catalyzed direct amination of benzylic hydrocarbons and inactive aliphatic alkanes with arylamines. Issue 17 (17th April 2020)

• Record Type: Journal Article
• Authors: Yao, Hua; Xie, Bo; Zhong, Xiaoyang; Jin, Shengzhou; Lin, Sen; Yan, Zhaohua
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 17(2020)
• Page Start: 3263
• Page End: 3268
• Publication Date: 2020-04-17
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob00491j
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A new synthetic method toward direct C–N bond formation through saturated C–H amination of benzylic hydrocarbons and inactive aliphatic alkanes with primary aromatic amines under an inexpensive catalyst/oxidant (Cu/DTBP) system has been developed. Abstract : A new synthetic method toward direct C–N bond formation through saturated C–H amination of benzylic hydrocarbons and inactive aliphatic alkanes with primary aromatic amines under an inexpensive catalyst/oxidant (Cu/DTBP) system has been developed. Both aminopyridines and anilines could react smoothly with primary and secondary benzylic C–H substrates or cyclohexane to form the corresponding aromatic secondary amines in moderate to good yields. This protocol has the advantages of wide functional group tolerance and use of readily available raw materials.