Development of a lateral flow test for rapid pyrethroid detection using antibody-gated indicator-releasing hybrid materials. Issue 10 (14th April 2020)

• Record Type: Journal Article
• Authors: Costa, Elena; Climent, Estela; Ast, Sandra; Weller, Michael G.; Canning, John; Rurack, Knut
• Is Part Of: Analyst. Volume 145:Issue 10(2020)
• Page Start: 3490
• Page End: 3494
• Publication Date: 2020-04-14
• Subjects: Chemistry, Analytic -- Periodicals; 543
• DOI: 10.1039/d0an00319k
• Languages: English
• ISSNs: 0003-2654

Abstract

Abstract : The employment of type-I pyrethroids for airplane disinfection in recent years underlines the necessity to develop sensing schemes for the rapid detection of these pesticides directly at the point-of-use. Abstract : The employment of type-I pyrethroids for airplane disinfection in recent years underlines the necessity to develop sensing schemes for the rapid detection of these pesticides directly at the point-of-use. Antibody-gated indicator-releasing materials were thus developed and implemented with test strips for lateral-flow assay-based analysis employing a smartphone for readout. Besides a proper matching of pore sizes and gating macromolecules, the functionalization of both the material's outer surface as well as the strips with PEG chains enhanced system performance. This simple assay allowed for the detection of permethrin as a target molecule at concentrations down to the lower ppb level in less than 5 minutes.