Inhibition of 3D colon cancer stem cell spheroids by cytotoxic RuII-p-cymene complexes of mesalazine derivatives. Issue 40 (14th April 2020)
- Record Type:
- Journal Article
- Title:
- Inhibition of 3D colon cancer stem cell spheroids by cytotoxic RuII-p-cymene complexes of mesalazine derivatives. Issue 40 (14th April 2020)
- Main Title:
- Inhibition of 3D colon cancer stem cell spheroids by cytotoxic RuII-p-cymene complexes of mesalazine derivatives
- Authors:
- Acharya, Sourav
Ghosh, Subhashis
Maji, Moumita
Parambil, Ajmal Roshan Unniram
Singh, Sandeep
Mukherjee, Arindam - Abstract:
- Abstract : Ru II - p -cymene complexes of imidazole–mesalazine based ligands kill bulk and stem colon cancer cells with tight regulation over stemness markers. Abstract : The Ru(ii ) complex of an imidazole–mesalazine Schiff base is a unique example showing growth inhibition of 3D-colon cancer stem cell spheroids and bulk colon cancer cells at lower dosage than salinomycin or oxaliplatin. Unlike oxaliplatin which increases the expression of stemness genes (SOX2, KLF4, HES1 and Oct4), these complexes maintain a tight regulation.
- Is Part Of:
- Chemical communications. Volume 56:Issue 40(2020)
- Journal:
- Chemical communications
- Issue:
- Volume 56:Issue 40(2020)
- Issue Display:
- Volume 56, Issue 40 (2020)
- Year:
- 2020
- Volume:
- 56
- Issue:
- 40
- Issue Sort Value:
- 2020-0056-0040-0000
- Page Start:
- 5421
- Page End:
- 5424
- Publication Date:
- 2020-04-14
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/d0cc00472c ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 13835.xml