Aerobic oxidative synthesis of quinazolinones and benzothiazoles in the presence of laccase/DDQ as a bioinspired cooperative catalytic system under mild conditions. Issue 24 (8th April 2020)

• Record Type: Journal Article
• Authors: Ghorashi, Nadia; Shokri, Zahra; Moradi, Reza; Abdelrasoul, Amira; Rostami, Amin
• Is Part Of: RSC advances. Volume 10:Issue 24(2020)
• Page Start: 14254
• Page End: 14261
• Publication Date: 2020-04-08
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9ra10303a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : In this paper laccase/DDQ as a bioinspired cooperative catalytic system was applied for the synthesis of quinazolinones and benzothiazoles using air or O2 as ideal oxidant in aqueous media under mild conditions. Abstract : The current study applied laccase/DDQ as a bioinspired cooperative catalytic system for the synthesis of quinazolinones (80–95% yield) and benzothiazoles (65–98% yield) using air or O2 as ideal oxidants in aqueous media at ambient temperature. The aerobic oxidative cyclization reactions occur in two steps: (i) chemical cyclization; (ii) chemoenzymatic oxidation. These methods are more environment-friendly, efficient, simple and practical than other reported methods due to the use of O2 as an oxidant, laccase as an eco-friendly biocatalyst, aqueous media as the solvent and free from any toxic transition metal and halide catalysts. Therefore, these methods can be applied in pharmaceutical and other sensitive synthetic procedures.