A dearomative ipso-iodocyclization/desymmetrization sequence leading to optically active tricyclic piperazine scaffolds. Issue 18 (25th April 2020)

• Record Type: Journal Article
• Authors: Okitsu, Takashi; Horike, Arisa; Shimazawa, Natsumi; Wada, Akimori
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 18(2020)
• Page Start: 3501
• Page End: 3511
• Publication Date: 2020-04-25
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob00510j
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A dearomative ipso -iodocyclization/desymmetrization sequence enabled the transformation from highly planar aromatic substrates to optically active tricyclic piperazine scaffolds. Abstract : Dearomative ipso -iodocyclization of 4-(1-ethoxyethoxy)- N -propargylanilines leading to 1-azaspiro[4.5]deca-3, 6, 9-trien-8-ones has been developed. This reaction is characterized by the yield of fewer toxic byproducts and is conducted by a more user-friendly protocol compared to other reported methods. The synthetic application of these spiro products was demonstrated by transformation of the iodo component into other functionalities. The desymmetrization of the resulting cyclohexadienones was also achieved by the diastereoselective aza-Michael addition of internal amino acid moieties to yield tricyclic piperazine scaffolds with two newly formed contiguous chiral centers.