Crystal engineering of nutraceutical phytosterols: new cocrystal solid solutions. Issue 25 (18th June 2020)

• Record Type: Journal Article
• Authors: Barbas, Rafael; Bofill, Lídia; de Sande, Dafne; Font-Bardia, Mercè; Prohens, Rafel
• Is Part Of: CrystEngComm. Volume 22:Issue 25(2020)
• Page Start: 4210
• Page End: 4214
• Publication Date: 2020-06-18
• Subjects: Crystals -- Periodicals; Crystal growth -- Periodicals; Crystallography -- Periodicals; Cristaux -- Périodiques; Cristaux -- Croissance -- Périodiques; Cristallographie -- Périodiques; 548
• DOI: 10.1039/d0ce00704h
• Languages: English
• ISSNs: 1466-8033

Abstract

Abstract : A cocrystal screening of solid solutions of three phytosterols (β-sitosterol, campesterol, stigmasterol) reveals that cocrystal solid solutions are enriched with β-sitosterol with respect to stigmasterol, a natural product with cytotoxicity concerns. Abstract : A cocrystal screening conducted with solid solutions of three phytosterols (β-sitosterol, campesterol and stigmasterol) and a set of coformers with strong hydrogen bond donors reveals that multicomponent solid solutions are preferentially formed instead of pure cocrystals and are much enriched with β-sitosterol with respect to stigmasterol, a natural product with cytotoxicity concerns.