Metal-free and solvent-free synthesis of m-terphenyls through tandem cyclocondensation of aryl methyl ketones with triethyl orthoformate. Issue 20 (25th March 2020)

• Record Type: Journal Article
• Authors: Xiao, Xiaoqin; Luo, Juan; Gan, Zongjie; Jiang, Wengao; Tang, Qiang
• Is Part Of: RSC advances. Volume 10:Issue 20(2020)
• Page Start: 12113
• Page End: 12118
• Publication Date: 2020-03-25
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d0ra00578a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A facile metal-free and solvent-free benzannulation was developed for the construction of m -terphenyl derivatives starting from aryl methyl ketones and triethyl orthoformate. This is a tandem reaction which merged six steps into one-pot procedure. Abstract : Reported here is a novel cyclocondensation of aryl methyl ketones and triethyl orthoformate for the simple synthesis of m -terphenyls. In the presence of a catalytic amount of TfOH, alkyl- and chloro-substituted acetophenones produced a series of terphenyls through a tandem reaction which merged six steps into a one-pot procedure. Moreover, the corresponding ester products were obtained when using other substituted acetophenones as the starting materials under the same reaction conditions.