Synthesis of fluorescent MOFs: live-cell imaging and sensing of a herbicide. Issue 26 (22nd June 2020)

• Record Type: Journal Article
• Authors: Mohanty, Aurobinda; Singh, Udai P.; Butcher, R. J.; Das, Neeladrisingha; Roy, Partha
• Is Part Of: CrystEngComm. Volume 22:Issue 26(2020)
• Page Start: 4468
• Page End: 4477
• Publication Date: 2020-06-22
• Subjects: Crystals -- Periodicals; Crystal growth -- Periodicals; Crystallography -- Periodicals; Cristaux -- Périodiques; Cristaux -- Croissance -- Périodiques; Cristallographie -- Périodiques; 548
• DOI: 10.1039/d0ce00490a
• Languages: English
• ISSNs: 1466-8033

Abstract

Abstract : Various metal–organic frameworks of Zn(ii ) and Cd(ii ) have been synthesized hydrothermally for the detection of herbicide (simazine) as well as nitro-aromatic compounds. Also these MOFs show live-cell imaging for MCF-7 cells. Abstract : Various zinc and cadmium containing metal–organic frameworks using the semi-rigid 1, 1′-(anthracene-9, 10-diylbis(methylene))bis(pyridin-1-ium-4-olate) ligand (L = AHP) and various sulfonic acid analogs [1, 5-naphthalenedisulfonic acid (1, 5-NDS), 3-sulfobenzoic acid (3-SBA), 4-sulfobenzoic acid (4-SBA), 5-sulfosalicylic acid (SSA), 5-sulfoisophthalic acid (SIA) and 2, 6-naphthalenedisulfonic acid (2, 6-NDS)] have been synthesized by a hydrothermal method. They have been characterized by powder X-ray diffraction thermogravimetric analysis and single crystal X-ray diffraction methods. The X-ray studies showed that MOF2, 4, and 8 have two dimensional architectures whereas 1, 3, 5, 6 and 7 have three-dimensional structures. The topological analysis demonstrated that all the zinc-containing MOFs have a hexagonal (hcb) net topology with the point symbol of the framework being {6 3 } whereas cadmium-containing MOF4 has an sql net topology with the point symbol of the framework being {4 4 ·6 2 } and MOF5 has a hcb net topology with the point symbol of the framework being {6 3 }. Since all synthesized MOFs have fluorescence properties, they have been used as imaging agents for MCF7 cells. The cytotoxic experiments show that more than 92% cells survive at the dose 100 μg ml −1 . The cell imaging results show that the MOF particles were found in the cytoplasm rather than in the nucleus and these can be used further as a conjugate with any known anti-cancer drugs in cellular distribution. The emission properties of these MOFs have been utilized for the detection of a herbicide (simazine) as well as nitroaromatic compounds. The quenching constant for PA (picric acid) in MOF7 was found to be 5.01 × 10 4 M −1, which may be due to the interaction of picric acid and co-ligands present in MOF7.