2D AuPd alloy nanosheets: one-step synthesis as imaging-guided photonic nano-antibiotics. Issue 8 (13th July 2020)

• Record Type: Journal Article
• Authors: He, Songliang; Zhu, Guoshuai; Sun, Zhencheng; Wang, Jidong; Hui, Ping; Zhao, Penghe; Chen, Wenwen; Jiang, Xingyu
• Is Part Of: Nanoscale advances. Volume 2:Issue 8(2020)
• Page Start: 3550
• Page End: 3560
• Publication Date: 2020-07-13
• Subjects: 620.5
• DOI: 10.1039/d0na00342e
• Languages: English
• ISSNs: 2516-0230

Abstract

Abstract : 2D noble metal nanomaterials in the field of photonic nano-antibiotics. Abstract : The complicated synthesis and undesirable biocompatibility of nanomaterials hinder the synergistic photothermal/photodynamic therapy for bacterial infections. Herein, we develop a one-step preparation method of 2D AuPd alloy nanosheets as imaging-guided photonic nano-antibiotics. 2D AuPd alloy nanosheets with an extremely small thickness (∼1.5 nm) exhibit prominent photothermal effects ( η = 76.6%), excellent ROS generation, strong photoacoustic signals and desirable biocompatibility. AuPd nanosheets can eliminate 100% of representative Gram-positive ( Staphylococcus aureus ) and Gram-negative bacteria ( Escherichia coli ) when irradiated using an 808 nm laser at 1 W cm −2 for 5 minutes. After being modified with a bacterial targeting peptide, under the guidance of photoacoustic imaging, AuPd nanosheets achieve promising synergistic photothermal/photodynamic therapeutic efficacy in treating Staphylococcus aureus infected mice. This work expands the biomedical application of 2D noble metal nanomaterials to the field of photonic nano-antibiotics.