Pillar[5]arene-based, dual pH and enzyme responsive supramolecular vesicles for targeted antibiotic delivery against intracellular MRSA. Issue 58 (17th June 2020)

• Record Type: Journal Article
• Authors: Peng, Haibo; Xie, Beibei; Yang, Xiaohong; Dai, Jiaojiao; Wei, Guoxing; He, Yun
• Is Part Of: Chemical communications. Volume 56:Issue 58(2020)
• Page Start: 8115
• Page End: 8118
• Publication Date: 2020-06-17
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc02522d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A rationally designed mannosylated amphiphilic pillar[5]arene (Man@AP5) self-assembles into supramolecular vesicles with encapsulated vancomycin (Man@AP5-Van), enhancing vancomycin's antibacterial efficacy against intracellular MRSA. Abstract : A rationally designed mannosylated amphiphilic pillar[5]arene (Man@AP5) self-assembles into supramolecular vesicles with encapsulated vancomycin (Man@AP5-Van), which target macrophages, respond to both acid and cathepsin B, and release vancomycin (Van) rapidly inside macrophages. Man@AP5-Van significantly increases the intracellular concentration of Van, enhancing its antibacterial efficacy against intracellular MRSA.