Rust-derived Fe2O3 nanoparticles as a green catalyst for the one-pot synthesis of hydrazinyl thiazole derivatives. Issue 24 (22nd April 2020)

• Record Type: Journal Article
• Authors: Gurav, Rutikesh; Surve, Santosh Kumar; Babar, Santosh; Choudhari, Prafulla; Patil, Devashree; More, Vikramsinh; Sankpal, Sandeep; Hangirgekar, Shankar
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 24(2020)
• Page Start: 4575
• Page End: 4582
• Publication Date: 2020-04-22
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob00109k
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A novel route of one-pot multicomponent reaction of tosylates, aryl aldehydes and thiosemicarbazide for the synthesis of hydrazinyl thiazole is reported using Fe2 O3 NPs derived from rust iron as a catalyst. Abstract : In the present work, novel one-pot multicomponent reactions of tosylates, aryl aldehydes and thiosemicarbazide are reported for the synthesis of hydrazinyl thiazoles, using Fe2 O3 NPs derived from rusted iron as a catalyst. The Fe2 O3 NPs were characterized using XRD, SEM, VSM, HR-TEM, EDX and FT-IR techniques. The structures of all of the synthesized hydrazinyl thiazole derivatives were confirmed by 1 H NMR, 13 C NMR, FT-IR and mass spectrometry. The magnetic Fe2 O3 NPs were easily recovered from the reactions using an external magnet, and the catalytic activity of the recycled catalyst was examined over four cycles under optimized reaction conditions; it exhibited minimal loss of yield. To explore potential applications, the synthesized molecules were investigated for their antibacterial, antifungal and antioxidant activities, and they showed promising results. The results were further supported through molecular docking studies.