Viscoelasticity of hydrazone crosslinked poly(ethylene glycol) hydrogels directs chondrocyte morphology during mechanical deformation. (30th June 2020)

• Record Type: Journal Article
• Authors: Richardson, Benjamin M.; Walker, Cierra J.; Macdougall, Laura J.; Hoye, Jack W.; Randolph, Mark A.; Bryant, Stephanie J.; Anseth, Kristi S.
• Is Part Of: Biomaterials science. Volume 8:Number 14(2020)
• Page Start: 3804
• Page End: 3811
• Publication Date: 2020-06-30
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1039/d0bm00860e
• Languages: English
• ISSNs: 2047-4830

Abstract

Abstract : Adaptable dynamic covalent crosslinks temporally modulate the biophysical transmission of physiologically relevant compressive strains to encapsulated chondrocytes for cartilage tissue engineering. Abstract : Chondrocyte deformation influences disease progression and tissue regeneration in load-bearing joints. In this work, we found that viscoelasticity of dynamic covalent crosslinks temporally modulates the biophysical transmission of physiologically relevant compressive strains to encapsulated chondrocytes. Chondrocytes in viscoelastic alky-hydrazone hydrogels demonstrated (91.4 ± 4.5%) recovery of native rounded morphologies during mechanical deformation, whereas primarily elastic benzyl-hydrazone hydrogels significantly limited morphological recovery (21.2 ± 1.4%).