An amide hydrogen bond templated [1]rotaxane displaying a peptide motif – demonstrating an expedient route to synthetic mimics of lasso peptides. Issue 27 (29th June 2020)

• Record Type: Journal Article
• Authors: Young, Matthew J.; Akien, Geoffrey R.; Evans, Nicholas H.
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 27(2020)
• Page Start: 5203
• Page End: 5209
• Publication Date: 2020-06-29
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob01190h
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : The rapid synthesis and characterization of an amide hydrogen bond templated [1]rotaxane – demonstrating a potential pathway to synthetic analogues of lasso peptides. Abstract : The rapid synthesis of an amide hydrogen bond templated [1]rotaxane is reported – demonstrating a potential pathway to synthetic analogues of lasso peptides. The structures of the [1]rotaxane and its unthreaded isomer have been characterized by NMR spectroscopy and modelled using DFT calculations.