Influence of nanomedicine mechanical properties on tumor targeting delivery. (26th March 2020)

• Record Type: Journal Article
• Authors: Li, Zheng; Xiao, Chen; Yong, Tuying; Li, Zifu; Gan, Lu; Yang, Xiangliang
• Is Part Of: Chemical Society reviews. Volume 49:Number 8(2020)
• Page Start: 2273
• Page End: 2290
• Publication Date: 2020-03-26
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cs00575g
• Languages: English
• ISSNs: 0306-0012

Abstract

Abstract : This tutorial review summarizes the influence of nanomedicine mechanical properties on drug delivery efficiency, antitumor efficacy and safety. Abstract : Modulating nanomedicine mechanical properties for enhanced drug delivery to tumors has attracted increasing attention in the past few decades. In this tutorial review, we analyze the impact of nanomedicine mechanical properties on in vivo transport processes and highlight the most recent advances in drug delivery efficiency and antitumor efficacy. Typical nanoparticles that have been explored for this purpose since 2000 are summarized while the methods to tune and the techniques to characterize nanomedicine mechanical properties are introduced. In the end, challenges and perspectives on tailoring nanomedicine mechanical properties for tumor targeting delivery are discussed.