Self-assembly of amphiphilic copolymers containing polysaccharide: PISA versus nanoprecipitation, and the temperature effect. Issue 29 (25th June 2020)

• Record Type: Journal Article
• Authors: Ikkene, Djallal; Arteni, Ana Andreea; Ouldali, Malika; Six, Jean-Luc; Ferji, Khalid
• Is Part Of: Polymer chemistry. Volume 11:Issue 29(2020)
• Page Start: 4729
• Page End: 4740
• Publication Date: 2020-06-25
• Subjects: Polymers -- Periodicals; Macromolecules -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1039/d0py00407c
• Languages: English
• ISSNs: 1759-9954

Abstract

Abstract : The self-assembly methods and the temperature have a considerable impact on the morphology of the resulting nanoobjects in the case of amphiphilic glycopolymers. Abstract : For many decades, the self-assembly of amphiphilic copolymers containing polysaccharide, called glycopolymers, has been induced in water via nanoprecipitation, whereas the polymerization-induced self-assembly (PISA) approach has been less reported. Using advanced characterization techniques including static/dynamic light scattering and negative-stain/cryo TEM analyses, we studied the impact of the experimental conditions/process on the morphology of formed glyco-nanostructures. A model amphiphilic glycopolymer (Dex-g 12 -PHPMA400 ) based on dextran as hydrophilic polysaccharide backbone and poly(2-hydroxypropyl methacrylate) (PHPMA) as hydrophobic grafts was prepared in water using photo-induced RAFT polymerization at 405 nm. On the one hand, our findings revealed that photo-initiated PISA (photo-PISA) at room temperature (RT) led to a mixture of spheres with a significant population of worm-like micelles (WLM), whereas the nanoprecipitation of purified Dex-g 12 -PHPMA400 led only to spherical micelles. On the other hand, we demonstrate that the morphology of glyco-nanostructures is affected by temperature since performing photo-PISA at 60 °C led to spheres instead of WLM. Finally, our findings revealed that pre-synthesized WLM at RT underwent irreversibly an unusual morphological transition to spheres by heating to 60 °C.