Dynamic modulation of proximity-induced enzyme activity using supramolecular polymers. Issue 43 (22nd April 2020)

• Record Type: Journal Article
• Authors: Magdalena Estirado, Eva; Rosier, Bas J. H. M.; de Greef, Tom F. A.; Brunsveld, Luc
• Is Part Of: Chemical communications. Volume 56:Issue 43(2020)
• Page Start: 5747
• Page End: 5750
• Publication Date: 2020-04-22
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc02120b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Synthetic supramolecular polymers are used as dynamic nanoscaffolds for the activation of the apoptotic signalling enzyme caspase-9. Abstract : Synthetic supramolecular polymers are used as dynamic nanoscaffolds for the activation of the apoptotic signalling enzyme caspase-9. Recruitment of caspase-9 to the nanoscaffold results in an increase in enzymatic activity due to enhanced proximity, with a bell-shaped response as a function of nanoscaffold concentration. The modularity of the system allows for dynamic regulation of enzyme activity through variation of the recruitment-motif density along the supramolecular polymer.