Nano-immunoimaging. Issue 4 (2nd January 2020)

• Record Type: Journal Article
• Authors: Wang, Ping; Kim, Taeho; Harada, Masako; Contag, Christopher; Huang, Xuefei; Smith, Bryan Ronain
• Is Part Of: Nanoscale horizons. Volume 5:Issue 4(2020)
• Page Start: 628
• Page End: 653
• Publication Date: 2020-01-02
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c9nh00514e
• Languages: English
• ISSNs: 2055-6756

Abstract

Abstract : Immunoimaging, stoked by the intriguing triumphs of immunotherapy, increasingly intersects with nanotechnology. Nanoimmunoimaging, the nascent field that emerged, applies nanoengineering principles to help resolve key challenges facing immunoimaging. Abstract : Immunoimaging is a rapidly growing field stoked in large part by the intriguing triumphs of immunotherapy. On the heels of immunotherapy's successes, there exists a growing need to evaluate tumor response to therapy particularly immunotherapy, stratify patients into responders vs. non-responders, identify inflammation, and better understand the fundamental roles of immune system components to improve both immunoimaging and immunotherapy. Innovative nanomaterials have begun to provide novel opportunities for immunoimaging, in part due to their sensitivity, modularity, capacity for many potentially varied ligands (high avidity), and potential for multifunctionality/multimodality imaging. This review strives to comprehensively summarize the integration of nanotechnology and immunoimaging, and the field's potential for clinical applications.