18F-Labeled dihydromethidine: positron emission tomography radiotracer for imaging of reactive oxygen species in intact brain. Issue 13 (19th February 2020)

• Record Type: Journal Article
• Authors: Egami, Hiromichi; Nakagawa, Satoshi; Katsura, Yuki; Kanazawa, Masakatsu; Nishiyama, Shingo; Sakai, Toshihiro; Arano, Yasushi; Tsukada, Hideo; Inoue, Osamu; Todoroki, Kenichiro; Hamashima, Yoshitaka
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 13(2020)
• Page Start: 2387
• Page End: 2391
• Publication Date: 2020-02-19
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob00126k
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Dihydromethidine (DHM) labeled with 18 F at the para position of the benzene ring has been developed as a positron emission tomography (PET) radiotracer for non-invasive imaging of reactive oxygen species (ROS). Abstract : Dihydromethidine (DHM) labeled with 18 F at the para position of the peripheral benzene ring was designed as a positron emission tomography (PET) radiotracer for non-invasive imaging of reactive oxygen species (ROS). This compound readily crosses the blood–brain barrier and is oxidized by ROS, and the oxidation product is retained intracellularly. PET imaging of ROS-producing rat brain microinfused with sodium nitroprusside identified specific brain regions with high ROS concentrations. This tracer should be useful for studies of the pathophysiological roles of ROS, and in the diagnosis of neurodegenerative diseases.