Aza-crown ether locked on polyethyleneimine: solving the contradiction between transfection efficiency and safety during in vivo gene delivery. Issue 41 (16th April 2020)

• Record Type: Journal Article
• Authors: Li, Shengran; Lin, Lin; Wang, Wenliang; Yan, Xinxin; Chen, Binggang; Jiang, Sangni; Liu, Sanrong; Ma, Xiaojing; Tian, Huayu; Yu, Xifei
• Is Part Of: Chemical communications. Volume 56:Issue 41(2020)
• Page Start: 5552
• Page End: 5555
• Publication Date: 2020-04-16
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc10041e
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An aza-crown ether derivative to lock a hyperbranched PEI, which endows the PEI with tumor targeting ability, antiserum ability and extended circulation in the blood, meanwhile retaining the high gene complexation and high transfection efficiency. Abstract : We proposed a method using an aza-crown ether derivative to lock a hyperbranched polyethyleneimine, which endows the PEI25k with tumor targeting ability, anti-serum ability and extended circulation in the blood meanwhile retaining the high gene complexation and high transfection efficiency. The method we proposed here simultaneously endows cationic materials with high transfection efficiency and high safety, which greatly pushed the cationic materials to be applied in in vivo gene delivery.