Transtubular potassium gradient predicts kidney function impairment after adrenalectomy in primary aldosteronism. (August 2020)

• Record Type: Journal Article
• Authors: Liao, Hung-Wei; Wang, Shuo-Meng; Chan, Chieh-Kai; Lin, Yen-Hung; Lin, Po-Chih; Ho, Chen-Hsun; Liu, Yu-Chun; Chueh, Jeff S; Wu, Vin-Cent
• Other Names: Lai Tai-Shuan non-byline-author.; Yang Shao-Yu non-byline-author.; Liu Kao-Lang non-byline-author.; Chang Chin-Chen non-byline-author.; Lee Bo-Chiag non-byline-author.; Huang Kuo-How non-byline-author.; Lin Lian-Yu non-byline-author.; Liao Shih-Cheng non-byline-author.; Yen Ruoh-Fang non-byline-author.; Lu Ching-Chu non-byline-author.; Er Leay-Kiaw non-byline-author.; Hu Ya-Hui non-byline-author.; Chang Chia-Hui non-byline-author.; Wu Che-Hsiung non-byline-author.; Tsai Yao-Chou non-byline-author.; Chueh Shih-Chieh Jeff non-byline-author.; Huang Wei-Chieh non-byline-author.; Chen Ying-Ying non-byline-author.; Wu Kwan-Dun non-byline-author.
• Is Part Of: Therapeutic advances in chronic disease. Volume 11(2020)
• Publication Date: 2020-08
• Subjects: adrenalectomy -- kidney function impairment -- primary aldosteronism -- transtubular potassium gradient; Chronic diseases -- Periodicals; Chronic diseases -- Treatment -- Periodicals; Chronic Disease -- Periodicals; Chronic Disease -- therapy -- Periodicals; 616.044
• DOI: 10.1177/2040622320944792
• Languages: English
• ISSNs: 2040-6223

Abstract

Background: In primary aldosteronism (PA), kidney function impairment could be concealed by relative hyperfiltration and emerge after adrenalectomy. We hypothesized transtubular gradient potassium gradient (TTKG), a kidney aldosterone bioactivity indicator, could correlate to end organ damage and forecast kidney function impairment after adrenalectomy. Methods: In the present prospective study, we enrolled lateralized PA patients who underwent adrenalectomy and were followed up 12 months after operation in the Taiwan Primary Aldosteronism Investigation (TAIPAI) registry from 2010 to 2018. The clinical outcome was kidney function impairment, defined as estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m 2 at 12 months after adrenalectomy. End organ damage is determined by microalbuminuria and left ventricular mass. Results: In total, 323 patients [mean, 50.8 ± 10.9 years old; female 178 (55.1%)] were enrolled. Comparing pre-operation and post-operation data, systolic blood pressure, serum aldosterone, urinary albumin to creatinine ratio and eGFR decreased. TTKG ⩾ 4.9 correlated with pre-operative urinary albumin to creatinine ratio >50 mg/g [odds ratio (OR) = 2.42; p = 0.034] and left ventricular mass (B = 20.10; p = 0.018). Multivariate logistic regression analysis demonstrated that TTKG ⩾ 4.9 could predict concealed chronic kidney disease (OR = 5.42; p = 0.011) and clinical success (OR = 2.90, p = 0.017) at 12 months after adrenalectomy. Conclusions: TTKG could predict concealed kidney function impairment and cure of hypertension in PA patients after adrenalectomy. TTKG more than 4.9 as an adverse surrogate of aldosterone and hypokalaemia correlated with pre-operative end organ damage in terms of high proteinuria and cardiac hypertrophy.