Magnetically targeted erythrocyte membrane coated nanosystem for synergistic photothermal/chemotherapy of cancer. Issue 18 (9th April 2020)

• Record Type: Journal Article
• Authors: Wang, Long; Chen, Sijie; Pei, Wenjing; Huang, Biying; Niu, Chengcheng
• Is Part Of: Journal of materials chemistry. Volume 8:Issue 18(2020)
• Page Start: 4132
• Page End: 4142
• Publication Date: 2020-04-09
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d0tb00364f
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Combination photothermal therapy (PTT)/chemotherapy has become an emerging cancer treatment strategy in recent years. Abstract : Combination photothermal therapy (PTT)/chemotherapy has become an emerging cancer treatment strategy in recent years. However, one of the important challenges in the development of nanomedicines is escaping immune recognition and the phagocytosis by the reticuloendothelial system (RES) to ultimately maximize tumor accumulation. In this work, a cell membrane-coated magnetically targeted drug delivery nanosystem was developed for synergistic PTT/chemotherapy of cancer. Importantly, this nanosystem can cleverly escape identification and clearance from the immune system, effectively prolong the blood circulation time and accurately accumulate in the target tumor tissues. This provides a new strategy to realize extraordinary antitumor effect by a unique design with cell membrane cloaking, magnetic targeting, drug delivery and synergistic PTT/chemotherapy.