Simultaneous co-assembly of fenofibrate and ketoprofen peptide for the dual-targeted treatment of nonalcoholic fatty liver disease (NAFLD). Issue 36 (2nd April 2020)

• Record Type: Journal Article
• Authors: Wang, Zhongyan; Ma, Chuanrui; Shang, Yuna; Yang, Lijun; Zhang, Jing; Yang, Cuihong; Ren, Chunhua; Liu, Jinjian; Fan, Guanwei; Liu, Jianfeng
• Is Part Of: Chemical communications. Volume 56:Issue 36(2020)
• Page Start: 4922
• Page End: 4925
• Publication Date: 2020-04-02
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc00513d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An ingenious co-assembled nanosystem based on fenofibrate and ketoprofen peptide for the dual-targeted treatment of NAFLD by reducing hepatic lipid accumulation and inflammatory responses. Abstract : We have developed a co-assembled nanosystem based on fenofibrate and ketoprofen by tactfully utilizing their simultaneous benzophenone interaction, which greatly enhances the bioavailability of fenofibrate and plays a role in the dual-targeted treatment of NAFLD by reducing hepatic lipid accumulation and inflammatory responses.