A two-dimensional MXene potentiates a therapeutic microneedle patch for photonic implantable medicine in the second NIR biowindow. Issue 18 (1st May 2020)

• Record Type: Journal Article
• Authors: Lin, Shiyang; Lin, Han; Yang, Mai; Ge, Min; Chen, Yu; Zhu, Yufang
• Is Part Of: Nanoscale. Volume 12:Issue 18(2020)
• Page Start: 10265
• Page End: 10276
• Publication Date: 2020-05-01
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/d0nr01444c
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : A soluble microneedle system loaded with two-dimensional MXene has been successfully fabricated, which can achieve in-situ photothermal therapy towards superficial tumor models with minimal invasion and high efficiency of drug delivery. Abstract : Due to the refractory nature and recurrence of cancer, the related treatments are continuously updated and improved. Here, we designed a soluble polyvinylpyrrolidone (PVP) microneedle system loaded with a two-dimensional (2D) MXene (Nb2 C nanosheets) for medical implantation and photothermal ablation of superficial tumors in the second near infrared biological window (NIR-II). In this system, 2D Nb2 C nanosheets acted as high-performance photothermal nanoagents, and biocompatible PVP functioned as matrix material to maintain the structure of the needles. The microneedle system exhibited sufficient skin-penetration ability and distinctive dissolution behavior. After being inserted into the skin of the tumor site, it can be dissolved within a short period to release the loaded 2D Nb2 C nanosheets. The temperature of the tumor site increased rapidly to almost 70 °C under the irradiation of a 1064 nm laser at a power density of 1 W cm −2, and this could provide sufficient conditions for photonic tumor ablation. After two weeks of treatment, the tumor growth was significantly suppressed, compared to that of the control group, and the survival rate of mice was clearly improved. In addition, the biocompatibility of the microneedle system was tested on mice, in which no significant toxicity or side effects were observed. Therefore, this kind of microneedle system with minimally invasive, safe and effective features is expected to be developed as an intriguing strategy for localized superficial cancer treatment.