Heat- or light-induced acylarylation of unactivated alkenes towards 3-(α-acyl) indolines. Issue 29 (14th July 2020)

• Record Type: Journal Article
• Authors: Li, Yanni; Ying, Fengyuan; Fu, Tingfeng; Yang, Ruihan; Dong, Ying; Lin, Liqing; Han, Yinghui; Liang, Deqiang; Long, Xianhao
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 29(2020)
• Page Start: 5660
• Page End: 5665
• Publication Date: 2020-07-14
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob01105c
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A heat- or photoredox/iron dual catalysis-enabled rare example of radical acylation across unactivated alkenes with aldehydes. Abstract : A heat- or photoredox/iron dual catalysis-enabled dehydrogenative acylarylation of N -allyl anilines leading to 2-substituted 3-(α-acyl) indolines with a quaternary stereogenic center is presented, with unactivated alkenic bonds as radical acceptors and simple aldehydes as radical precursors. This reaction features high yields, a broad substrate scope, and a great exo selectivity, and gram-scale syntheses could be readily carried out.