Conversion of racemic alcohols to optically pure amine precursors enabled by catalyst dynamic kinetic resolution: experiment and computation. Issue 64 (8th July 2020)

• Record Type: Journal Article
• Authors: Azofra, Luis Miguel; Tran, Mai Anh; Zubar, Viktoriia; Cavallo, Luigi; Rueping, Magnus; El-Sepelgy, Osama
• Is Part Of: Chemical communications. Volume 56:Issue 64(2020)
• Page Start: 9094
• Page End: 9097
• Publication Date: 2020-07-08
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc02881a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An unprecedented base metal catalysed asymmetric synthesis of α-chiral amine precursors from racemic alcohols is reported. Abstract : An unprecedented base metal catalysed asymmetric synthesis of α-chiral amine precursors from racemic alcohols is reported. This redox-neutral reaction utilises a bench-stable manganese complex and Ellman's sulfinamide as a versatile ammonia surrogate. DFT calculations explain the unusual finding of the highly stereoselective transformation enabled by a catalyst that undergoes an unusual dynamic kinetic resolution.