Regioselective synthesis and anticancer evaluation of H2O2-activable nucleosides. Issue 48 (27th May 2020)

• Record Type: Journal Article
• Authors: Sun, Ying-Jie; Liu, Li; Cheng, Liang
• Is Part Of: Chemical communications. Volume 56:Issue 48(2020)
• Page Start: 6484
• Page End: 6487
• Publication Date: 2020-05-27
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc02245d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : We reported herein the design and synthesis of H2 O2 -activatable nucleosides via an efficient synthesis and their biological evaluation against cancer cells. Abstract : We describe here the design, synthesis, and biological evaluation of H2 O2 -activatable nucleosides via an efficient and regioselective functionalization of unprotected precursors. Biological evaluation of a H2 O2 -specific responsive prodrug of gemecitabin demonstrates an extremely fast activation, low toxicity and enhanced anticancer effects in two cell lines.