Cisplatin binds to the MDM2 RING finger domain and inhibits the ubiquitination activity. Issue 33 (25th March 2020)

• Record Type: Journal Article
• Authors: Cao, Kaiming; Ding, Xin; Sheng, Yaping; Wang, Yu; Liu, Yangzhong
• Is Part Of: Chemical communications. Volume 56:Issue 33(2020)
• Page Start: 4599
• Page End: 4602
• Publication Date: 2020-03-25
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc00203h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Cisplatin binds to the RING finger of MDM2, leading to the zinc-release and protein unfolding, resulting in the inhibition of MDM2-mediated ubiquitination. Abstract : Cisplatin can directly bind to the RING finger domain of MDM2, leading to the zinc-release and protein unfolding. Consequently, cisplatin inhibits the MDM2-mediated ubiquitination, which is the molecular basis of p53 activation. This work provides insight into the cisplatin-induced p53-elevation that is involved in cell apoptosis.