Platinum-carbon-integrated nanozymes for enhanced tumor photodynamic and photothermal therapy. Issue 25 (18th June 2020)

• Record Type: Journal Article
• Authors: Yang, Yang; Zhu, Daoming; Liu, Ying; Jiang, Bing; Jiang, Wei; Yan, Xiyun; Fan, Kelong
• Is Part Of: Nanoscale. Volume 12:Issue 25(2020)
• Page Start: 13548
• Page End: 13557
• Publication Date: 2020-06-18
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/d0nr02800b
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Tumor hypoxia compromises the effects of photodynamic therapy that consumes oxygen in the therapeutic process. Abstract : Tumor hypoxia compromises the effects of photodynamic therapy that consumes oxygen in the therapeutic process. Herein, a platinum (Pt)-carbon-integrated nanozyme with favorable catalase-like activity and photosensitizing properties was successfully constructed by immobilizing an ultrasmall Pt nanozyme into a MOF-derived carbon nanozyme through an in situ reduction strategy. The integration of a Pt nanozyme significantly improves the catalase activity of a carbon nanozyme that can effectively catalyze the decomposition of endogenous hydrogen peroxide to produce oxygen to improve the effects of photodynamic therapy. In addition, the integration of a Pt nanozyme also enhances the intrinsic photothermal performance of a carbon nanozyme. Combining the improved catalase-like activity with the enhanced photothermal properties together, the Pt-carbon nanozyme exhibits remarkable tumor inhibition ability in vivo . Thus, utilizing the enzymatic activity and photothermal/photosensitizing properties of nanozymes has great potential to overcome the limitations of traditional therapeutic strategies, and could inspire new directions for nanozyme-based biomedical applications.