Biodegradable phosphorylcholine copolymer for cardiovascular stent coating. Issue 24 (27th May 2020)

• Record Type: Journal Article
• Authors: Liu, Jun; Wang, Jing; Xue, Yun-fan; Chen, Ting-ting; Huang, Dan-ni; Wang, You-xiang; Ren, Ke-feng; Wang, Yun-bing; Fu, Guo-sheng; Ji, Jian
• Is Part Of: Journal of materials chemistry. Volume 8:Issue 24(2020)
• Page Start: 5361
• Page End: 5368
• Publication Date: 2020-05-27
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d0tb00813c
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : A biodegradable phosphorylcholine-based copolymer synthesized via one-step radical ring-opening polymerization may be a promising material for biodegradable stent coating. Abstract : Phosphorylcholine (PC) based polymer coatings with excellent biocompatibility have shown successful commercialization in drug-eluting stents. However, poor degradability represents a challenge in the application of biodegradable stents. Herein, a biodegradable phosphorylcholine copolymer is developed based on one-step radical ring-opening polymerization (RROP). This copolymer was synthesized by copolymerization of a PC unit, degradable ester (2-methylene-1, 3-dioxepane, MDO) unit and non-degradable butyl methacrylate (BMA) unit, which showed ratio controllability by changing the monomer ratio during polymerization. We demonstrated that the copolymer with the ratio of 34% MDO, 19% MPC and 47% BMA could form a stable coating by ultrasonic spray, and showed good blood compatibility, anti-adhesion properties, biodegradability, and rapamycin eluting capacity. In vivo study revealed its promising application as a biodegradable stent coating. This work provides a facile path to add biodegradability into PC based polymers for further bio-applications.