Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria. Issue 18 (30th April 2020)

• Record Type: Journal Article
• Authors: Parker, Hadyn L.; Tomás, Ruben M. F.; Furze, Christopher M.; Guy, Collette S.; Fullam, Elizabeth
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 18(2020)
• Page Start: 3607
• Page End: 3612
• Publication Date: 2020-04-30
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob00253d
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Chemoenzymatic synthesis of azido-functionalised asymmetric trehalose analogues that are resistant to enzymatic degradation to probe carbohydrate processing pathways in mycobacteria. Abstract : The uptake and metabolism of the disaccharide trehalose by Mycobacterium tuberculosis is essential for the virulence of this pathogen. Here we describe the chemoenzymatic synthesis of new azido-functionalised asymmetric trehalose probes that resist degradation by mycobacterial enzymes and are used to probe trehalose processing pathways in mycobacteria.