All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery. (3rd June 2020)

• Record Type: Journal Article
• Authors: Costa, Clarinda; Liu, Zehua; Martins, João P.; Correia, Alexandra; Figueiredo, Patrícia; Rahikkala, Antti; Li, Wei; Seitsonen, Jani; Ruokolainen, Janne; Hirvonen, Sami-Pekka; Aguiar-Ricardo, Ana; Corvo, M. Luísa; Santos, Hélder A.
• Is Part Of: Biomaterials science. Volume 8:Number 12(2020)
• Page Start: 3270
• Page End: 3277
• Publication Date: 2020-06-03
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1039/d0bm00743a
• Languages: English
• ISSNs: 2047-4830

Abstract

Abstract : Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral insulin delivery system is reported. This system represents a promising alternative for the common protein/peptide-loaded liposome formulations. Abstract : Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral delivery system is reported. Insulin is successfully encapsulated into liposomes, which are coated with chitosan to improve their mucoadhesion. The encapsulation in an enteric polymer offers protection from the harsh gastric conditions. Insulin permeability is enhanced across an intestinal monolayer.