Chemoenzymatic synthesis of 3-deoxy-3-fluoro-l-fucose and its enzymatic incorporation into glycoconjugates. Issue 47 (11th May 2020) - Valverde, Pablo
Abstract : A chemoenzymatic synthesis of 3-deoxy-3-fluoro-l -fucose, using a d - to l -sugar translation strategy, and its enzymatic activation and glycosylation, is reported. Abstract : The first synthesis of 3-deoxy-3-fluoro-l -fucose is presented, which employs a d - to l -sugar translation strategy, and involves an enzymatic oxidation of 3-deoxy-3-fluoro-l -fucitol. Enzymatic activation (FKP) and glycosylation using an α-1, 2 and an α-1, 3 fucosyltransferase to obtain two fluorinated trisaccharides demonstrates its potential as a novel versatile chemical probe in glycobiology.