Dual-binding conjugates of diaromatic guanidines and porphyrins for recognition of G-quadruplexes. Issue 29 (10th July 2020)

• Record Type: Journal Article
• Authors: Grover, Jagdeep; Trujillo, Cristina; Saad, Mona; Emandi, Ganapathi; Stipaničev, Nikolina; Bernhard, Stefan S. R.; Guédin, Aurore; Mergny, Jean-Louis; Senge, Mathias O.; Rozas, Isabel
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 29(2020)
• Page Start: 5617
• Page End: 5624
• Publication Date: 2020-07-10
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob01264e
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : The first conceptualised class of dual-binding guanine quadruplex binders has been designed, synthesised and biophysically studied. Abstract : The first conceptualised class of dual-binding guanine quadruplex binders has been designed, synthesised and biophysically studied. These compounds combine diaromatic guanidinium systems and neutral tetra-phenylporphyrins (classical binding moiety for guanine quadruplexes) by means of a semi-rigid linker. An extensive screening of a variety of guanine quadruplex structures and double stranded DNA via UV-vis, FRET and CD experiments revealed the preference of the conjugates towards guanine quadruplexes. Additionally, docking studies indicate the potential dual mode of binding.